Association between dyslipidemia and carotid plaque incidence in a research group: a prospective cohort study
10.3760/cma.j.issn.0254-6450.2019.03.016
- VernacularTitle: 某科研人群血脂异常与颈动脉斑块发病关系的前瞻性队列研究
- Author:
Jian LIU
1
;
Xuehua MA
1
;
Leyuan YAN
1
;
Miao LIU
2
,
3
,
4
,
5
;
Shengshu WANG
2
,
3
,
4
,
5
;
Yao HE
2
,
3
,
4
,
5
Author Information
1. Physical Examination Center, The Fourth Medical Center of People’s Liberation Army General Hospital, Beijing 100037, China
2. Institute of Geriatrics, Chinese People’s Liberation Army General Hospital, Beijing 100853, China
3. Beijing Key Laboratory of Research on Aging and Related Diseases, Chinese People’s Liberation Army General Hospital, Beijing 100853, China
4. State Key Laboratory of Kidney Disease, Chinese People’s Liberation Army General Hospital, Beijing 100853, China
5. National Clinical Research Center for Geriatrics Diseases, Chinese People’s Liberation Army General Hospital, Beijing 100853, China
- Publication Type:Journal Article
- Keywords:
Dyslipidemia;
Carotid plaque;
Cohort study;
Prospective study
- From:Chinese Journal of Epidemiology
2019;40(3):341-345
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the association and intensity of baseline dyslipidemia with the incidence of carotid plaque in a researchers group in China.
Methods:A total of 716 researchers were enrolled in this prospective cohort study. Dyslipidemia was assessed in 2010. Follow-up study on carotid plaque was conducted in 2017.
Results:Over 8 years’ follow-up, 289 carotid plaque patients were identified among 716 individuals who did not have carotid plaque at baseline survey, with cumulative incidence of 40.36%. After adjustment of age, gender, BMI, waist circumference, FPG, SBP, DBP, ALT and uric acid, compared with non-dyslipidemia group, HR of carotid plaque for such populations with ≥3 types of dyslipidemia was 1.681 (95%CI: 1.090--2.593).
Conclusions:Dyslipidemia might be associated with higher risk of carotid plaque, and population with ≥3 types of dyslipidemia had higher risk for carotid plaque. Prevention of dyslipidemia or reduction of types of dyslipidemia might be one of the effective precautions for prevention of carotid plaque.
