The expression and clinical significance of lncRNA-uc003jsd.1 in congenital microtia
10.3760/cma.j.issn.1009-4598.2019.03.015
- VernacularTitle: 长链非编码RNA-uc003jsd.1在先天性小耳畸形中的表达及临床意义
- Author:
Ling ZHANG
1
;
Lin LIN
;
Yupeng SONG
;
Bo PAN
;
Qinghua YANG
;
Haiyue JIANG
Author Information
1. Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100144, China
- Publication Type:Journal Article
- Keywords:
Congenital microtia;
lncRNA;
uc003jsd.1
- From:
Chinese Journal of Plastic Surgery
2019;35(3):285-288
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of long non-coding RNA(lncRNA) uc003jsd.1 in congenital microtia and its clinical significance.
Methods:Real-time quantitative polymerase chain reaction (Real-time PCR) was used to detect the expression of lncRNA-NR_028308 in the residual ear cartilage and normal ear cartilage of 8 patients with microtia.
Results:The expression of uc003jsd.1 was significantly higher in the residual ear cartilage (P=0.015) than paired normal tissues.
Conclusions:LncRNA-uc003jsd.1 is up-regulated in the cartilage of the congenital microtia, suggesting a certain relationship with the development of congenital microtia.
