Therapeutic effect of antitoxin on botulism type A: a preliminary observation of 8 cases
10.3760/cma.j.issn.1009-4598.2019.03.014
- VernacularTitle: 抗毒素治疗八例A型肉毒毒素中毒疗效的初步观察
- Author:
Chen CHENG
1
;
Yun XIE
;
Rui JIN
;
Jizhou HE
;
Bojun CHEN
;
Qingfeng LI
Author Information
1. Plastic and Reconstructive Surgery, Shanghai Ninth People′s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
- Publication Type:Journal Article
- Keywords:
Botulinum Toxin Type A;
Botulism;
Antitoxin;
Electromyography
- From:
Chinese Journal of Plastic Surgery
2019;35(3):282-284
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The study aimed to explore the recommended treatment for toxicosis of botulism toxin type A.
Methods:From January 2016 to August 2017, 8 patients with toxicosis of botulism toxin type A were hospitalized in Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine. All patients were female, 21-33 years of age, with an average age of 26.4 years. All patients showed progressive myasthenia and abnormal electromyography. The clinical manifestations and treatment outcomes of 8 patients in antitoxin group or non-antitoxin group were retrospectively analyzed. Five patients treated in plastic and reconstructive surgery department were included in the antitoxin group. They received skin test before injection, followed by intramuscular injection of 10 000-20 000 U antitoxins once a day for 2-3 days. Three patients treated in neurology department were included in the non-antitoxin group. They received only intravenous drip of neurotrophic drugs. After treatment, the improvement of clinical symptoms such as myasthenia and blepharoptosis was observed, and the electromyogram was followed up.
Results:The symptoms of myasthenia of the 5 patients in antitoxin treatment group were significantly improved, and the electromyogram signal returned to normal. However, for the 3 patients in non-antitoxin group, the symptoms of myasthenia did not significantly improve, and their electromyogram signal did not return to normal, even after 5 days′continuous treatment.
Conclusions:To regulate the cosmetic medical market is the key to prevent the accident of toxicosis of botulism toxin type A. It is necessary to make a definite diagnosis and medical intervene in time for the toxicosis. Antitoxin has a better curative effect, but further research is needed, to verify its safety and effectiveness.
