Research progress in neurotoxicity of HIV-1 viral protein R
10.3760/cma.j.issn.1003-9279.2019.03.020
- VernacularTitle: HIV-1病毒蛋白R的神经毒性作用研究进展
- Author:
Xinyue CAO
1
;
Li ZHAO
Author Information
1. Department of Laboratory Science of Sanitary Microbiology, School of Public Health, Shandong University, Key Laboratory of the 13th Five-Year University of Shandong Province, Key Laboratory of Infectious Disease Prevention and Control.Jinan 250012, China
- Publication Type:Review
- Keywords:
Human immunodeficiency virus-1;
Vral protein R;
Neurotoxicity
- From:
Chinese Journal of Experimental and Clinical Virology
2019;33(3):323-326
- CountryChina
- Language:Chinese
-
Abstract:
Viral Protein R (Vpr) is an accessory protein of HIV-1 that increases the infectivity of HIV-1, activates latent viruses, and acts with other accessory proteins. A number of studies have demonstrated the important role of Vpr in the pathogenesis of HIV-1 related neurological diseases. Vpr can disrupt the integrity of the blood-brain barrier, induce neuronal apoptosis, and may be an important causative agent of AIDS dementia syndrome. However, the exact mechanism is still unknown. This review elaborates the neurotoxic effects of HIV-1 Vpr.
