Study on the difference of blood routine and coagulation function between mild and severe patients of severe fever with thrombocytopenia syndrome
10.3760/cma.j.issn.1003-9279.2019.03.013
- VernacularTitle: 轻症和重症发热伴血小板减少综合征的血常规和凝血功能差异研究
- Author:
Hongyi XUE
1
;
Zhoujun BAO
2
;
Feng ZHU
1
;
Yunchen LI
3
;
Hanbo FANG
2
;
Yan WANG
3
;
Shibo LI
3
Author Information
1. Department of Hematology, Zhoushan Hospital Affiliated to Wenzhou Medical University, zhoushan 316021, China
2. Clinical Lab, Zhoushan Hospital Affiliated to Wenzhou Medical University, Zhoushan 316021, China
3. Department of Hospital Infection, Zhoushan Hospital Affiliated to Wenzhou Medical University, Zhoushan 316021, China
- Publication Type:Journal Article
- Keywords:
Severe fever with thrombocytopenia syndrome;
Coagulation function;
Receiver operating characteristic curve;
White blood cell
- From:
Chinese Journal of Experimental and Clinical Virology
2019;33(3):287-290
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical value of blood routine tests (RT) and coagulation function in differential diagnosis of mild and severe patients infected with bunyamwera virus.
Methods:Twenty-five mild patients and 25 severe patients infected with bunyamwera virus were selected and their blood RT and coagulation function tests were performed.
Results:The earliest prothrombin time (PT-early) and activated partial thromboplastin time(APTT-early) were significantly lower than those of severe patients(t=-2.43, P<0.05; t=-2.53, P<0.05). The lowest values of white blood cells (WBC-low) of mild patients were significantly higher than those of severe patients (t=5.66, P<0.01). The highest value of D-dimer (DD-high) of mild patients were significantly lower than that of severe patients (z=1.35, P<0.05). When mild patients values were set as outcome variable, AUC of APTT-early was the highest (AUC=0.713, P<0.05). When values of severe patients were set as outcome variable, AUC of DD-high was the highest (AUC=0.874, P<0.01).
Conclusions:APTT-early and DD-high are suitable for differential diagnosis of mild and severe patients infected with bunyamwera virus.
