Molecular prevalence and clinical characteristics of human metapneumovirus and human bocavirus in 333 hospitalized children with community-acquired pneumonia
10.3760/cma.j.issn.1003-9279.2019.03.008
- VernacularTitle: 333例社区获得性肺炎住院儿童中人偏肺病毒和博卡病毒的分子流行及临床特征
- Author:
Qian WANG
1
;
Meng SU
2
,
3
;
Dan LI
2
,
3
;
Luanying DU
2
,
3
;
Qing ZHANG
4
;
Hong WANG
4
;
Jianying LIU
1
;
Guangcheng XIE
2
,
3
Author Information
1. No.2 Clinical Teaching Hospital, Chengde Medical University, Chengde 067000, China
2. Department of Pathogenic Biology, Chengde Medical University, Chengde 067000, China
3. Laboratory for Pathogen Prevention and Control, Chengde Medical University, Chengde 067000, China
4. National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
- Publication Type:Journal Article
- Keywords:
Community-acquired pneumonia;
Human metapneumovirus;
Human bocavirus;
Hospitalized children
- From:
Chinese Journal of Experimental and Clinical Virology
2019;33(3):261-266
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the molecular prevalence and clinical characteristics of human metapneumovirus and human bocavirus in hospitalized children with community-acquired pneumonia.
Methods:Total 333 throat swabs and clinical information of patients were collected between 2017 and 2018 at Department of Pediatrics of No.2 Clinical Teaching Hospital, Chengde Medical University. The IgM of adenovirus (AdV), respiratory syncytial virus (RSV), influenza virus-A/B (Influ-A/B), parainuenza viruses (PIVs)were tested by detection kit, and the positive samples of human metapneumovirus (hMPV), human bocavirus (HBoV), AdV, RSV and human coronavirus (HCoV) were detected by RT-PCR or PCR.
Results:43 cases, 19 cases, 3 cases and 2 cases were positive for Influ-B, PIV, RSV and AdV IgM, respectively. Total 80 cases were infected with hMPV (71 cases were single infection, 8 cases were double infection, and 1 case was triple infection), 22 cases were infected with HBoV (14 cases were single infection, 7 cases were double infection, and 1 case was triple infection), 6 cases were infected with AdV (4 cases were single infection, 1 case was double infection, and 1 case was triple infection), only 1 case was single infected with RSV or HCoV, respectively. 39 cases (11.7%) and 41 cases (12.3%) were distributed at <5 years group and ≥5 years group, respectively. 45.0%(18/40)in severe cases and 27.99%(82/293)in mild cases were positive for hMPV, HBoV, AdV, RSV and HCoV, the ratio of viral positive case was significant higher in severe cases than mild cases (P=0.042). The age (P=0.000), peak of fever (P=0.035), duration of hospitalization (P=0.000), neutrophils (P=0.000) and lymphocytes (P=0.000) were significant difference in severe cases compared with mild cases.
Conclusions:Multiple respiratory viruses can cause community-acquired pneumonia and more attention should be pay to the surveillance of hMPV and HBoV.
