Clinical features of 406 cases of dengue fever in Guangzhou from 2015 to 2018
10.3760/cma.j.issn.1003-9279.2019.03.007
- VernacularTitle: 2015—2018年广州406例登革热临床特征分析
- Author:
Zhenghua XIE
1
;
Duoduo LIU
2
;
Shihuan TANG
1
;
Ying YUAN
1
;
Yue CHEN
3
;
Manjun CHEN
1
;
Xixia DING
1
;
Nan YU
1
Author Information
1. Department of Clinical Laboratory, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China
2. Department of Clinical Laboratory, Zengcheng Branch of Nanfang Hospital of Southern Medical University, Guangzhou 511300, China
3. Center for Disease Control and Prevention of Guangzhou Military Command of the People′s Liberation Army, Guangzhou 510507, China
- Publication Type:Journal Article
- Keywords:
Dengue fever;
Dengue virus;
Clinical features
- From:
Chinese Journal of Experimental and Clinical Virology
2019;33(3):257-260
- CountryChina
- Language:Chinese
-
Abstract:
Objective:By analyzing the clinical features of patients with dengue fever in Guangzhou from 2015 to 2018 to furnish the reference evidences for the diagnoses and treatment of dengue fever.
Methods:A total of 406 dengue fever patients admitted to Zhujiang hospital during 2015 to 2018 were analyzed for the clinical manifestations and laboratory examination results, retrospectively. ZIKV, CHIKV and the serotypes of DENV were detected in some samples.
Results:DENV serotypes were tested in 96 dengue fever patients and 69 cases were positive. Among them, 58 cases (84.1%) were DENV-1, 10 cases (14.5%) were DENV-2, 1 case (1.5%) was DENV-3, DENV-4 was negative and no co-infection with different serotypes of dengue virus was found. Of all the 406 patients, 371 (91.4%) were diagnosed as dengue fever and 35 (8.6%) were severe cases. The most common manifestations included fever, weakness and rash. Significantly higher incidence (P<0.05) of bleeding, coughing, expectoration, vomiting and abdominal pain were found in severe dengue fever. The most common laboratory findings were leucopenia and thrombocytopenia. Significant increase(P<0.05) of total bilirubin, aspartate aminotransferase, serum creatinine, high-sensitivity C-reactive protein and procalcitonin were observed. ZIKV and CHIKV nucleic acids were tested in 380 dengue fever patients and the result were negative for both.
Conclusions:The incidence of dengue fever in Guangzhou increased in 2017 and 2018.Most cases of dengue fever were mild and DENV-1 was the dominant serotype.
