From coding sequence to non-protein coding region: advances in cleft lip and palate genetic mechanism researches
10.3760/cma.j.issn.1002-0098.2019.03.012
- VernacularTitle: 从蛋白编码区到非蛋白编码区
- Author:
Yunfan ZHANG
1
;
Jiuxiang LIN
;
Feng CHEN
Author Information
1. Department of Orthodontics, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China
- Publication Type:Review
- Keywords:
Cleft lip;
Cleft palate;
Non-protein coding region;
Genetic mechanism;
Whole exome sequencing
- From:
Chinese Journal of Stomatology
2019;54(3):205-208
- CountryChina
- Language:Chinese
-
Abstract:
With the continuous development of bioinformatics technology and precision medicine, genetic mechanism investigations of genetic diseases including cleft lip and palate (CLP) have been getting more and more attention. Researchers have focused on the coding sequence of the genome and successfully found many CLP causative mutations, but there still remain some unsolved questions. In recent years, researchers′ vision has gradually shifted to non-protein coding region of the genome. This article reviews several coding sequence mutations, non-protein coding variants and their genetic mechanisms discovered in CLP researches.
