Role and potential value of circular RNAs in the occurrence of primary hepatic cancer

VernacularTitle: 环状RNA在原发性肝癌发生中的作用及其潜在价值
Author: Zhenluo JIANG ^{1
,

2} ; Lili SHEN ^{1
,

2} ; Yaoren HU ^{3
,

4} ; Junming GUO ¹ ; Liyun FU ^{1
,

2
,

4}
Author Information

1. Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China
2. Department of Hepatology, Ningbo No.2 Hospital, Ningbo 315020, China
3. Department of Hepatology, Ningbo No.2 Hospital, Ningbo 315020, China
4. Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, Ningbo 315020, China
Publication Type:Review
Keywords: Carcinoma, hepatocellular; Circular RNA; MicroRNA; Biomarker
From: Chinese Journal of Hepatology 2019;27(2):157-160
CountryChina
Language:Chinese
Abstract: Circular RNA is a class of non-coding RNAs, which are covalently closed and circular at both ends, showing dissimilar characteristics from linear RNA. Several studies have shown that circular RNAs play an important role in the occurrence and development of primary hepatic cancer. By combining with the latest research progress of this field at home and abroad, we summarized the mechanism regulating the occurrence and development of liver cancer, abnormal expression, and as potential molecular markers for disease diagnosis and treatment.