Research advancement of long non-coding RNAs in liver fibrosis
10.3760/cma.j.issn.1007-3418.2019.02.016
- VernacularTitle: 长链非编码RNA在肝纤维化中的研究进展
- Author:
Jiayu LIN
1
,
2
,
3
;
Zhenghua GONG
4
;
Jie ZHENG
5
;
Guoxin HU
4
Author Information
1. Graduate Institute, Guangzhou Medical University, Guangzhou 511436, China
2. Infection Department, Peking University Shenzhen Hospital, Shenzhen 518036, China
3. Gastroenterology Department, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China
4. Infection Department, Peking University Shenzhen Hospital, Shenzhen 518036, China
5. Traditional Chinese Medicine Department, Peking University Shenzhen Hospital, Shenzhen 518036, China
- Publication Type:Review
- Keywords:
Liver cirrhosis;
Hepatic stellate cell;
Long non-coding RNAs
- From:
Chinese Journal of Hepatology
2019;27(2):149-152
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic fibrosis is a wound healing and scar repair reaction after liver injury, and is a common pathway for various chronic liver diseases. Activation and proliferation of hepatic stellate cells are the key links in the occurrence and development of hepatic fibrosis. Recent studies have shown that long non-coding RNAs are involved in regulating the activation, proliferation and apoptosis of hepatic stellate cells. Thus, probing its mechanism of action will provide a new strategy for the diagnosis, treatment and prognosis in liver fibrosis.
