Identifying immunization strategy for preventing mother-to-child transmission of hepatitis B virus
10.3760/cma.j.issn.1007-3418.2019.02.005
- VernacularTitle: 关于进一步完善预防乙型肝炎病毒母婴传播免疫策略的探讨
- Author:
Jie LI
1
;
Ying LU
;
Kaiping WEI
;
Xin ZHANG
Author Information
1. Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science center, Beijing 100083, China
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Mother-to-child transmission;
Immunization strategy
- From:
Chinese Journal of Hepatology
2019;27(2):97-101
- CountryChina
- Language:Chinese
-
Abstract:
In 2016, the World Health Assembly endorsed the Global Health Sector Strategy on viral hepatitis, with aim to eliminate viral hepatitis as a public health threat by 2030, which may reduce the number of new cases of chronic hepatitis B by 90% (0.1% HBsAg prevalence among children) and mortality rate by 65%. In order to achieve this goal, blocking mother-to-child transmission of hepatitis B virus (HBV) is of paramount importance, especially in underdeveloped areas with high prevalence of HBV. In this paper, we discussed the status of chronic HBV infection and its serological and virological characteristics in women of childbearing age in China as well as the optimal dose of immunoglobulin in the combined passive-active immunoprophylaxis in infants born to HBsAg-positive mothers. In addition, the strategies for preventing mother-to-child transmission of HBV in terms of post-immunization testing, increased-dose vaccination (certainty/uncertainty) and follow-up of these infants.
