The effect of the interaction between apolipoprotein B mRNA editing enzyme-catalytic polypeptidelike 3G and viral infectivity factor on HIV-1 replication
10.3760/cma.j.issn.1003-9279.2019.02.023
- VernacularTitle: APOBEC3G与Vif的相互作用及其对HIV复制的影响
- Author:
Yu ZHANG
1
;
Jingyun LI
Author Information
1. Institute of Microbiology and Epidemiology, Academy of Military Medical Science, Beijing, 100071, China
- Publication Type:Review
- Keywords:
HIV-1;
APOBEC3G;
Vif
- From:
Chinese Journal of Experimental and Clinical Virology
2019;33(2):221-224
- CountryChina
- Language:Chinese
-
Abstract:
Apolipoprotein B mRNA editing enzyme-catalytic polypeptidelike 3G (APOBEC3G), which belongs to the APOBEC family, restricts the replication of HIV-1 through the deminase-dependent and deminase-independent antiviral mechanisms. Viral infectivity factor (Vif), an accessory protein edited by vif gene of HIV-1, promotes APOBEC3G ubiquitination and subsequent degradation by the proteasome result ing in the increased replication of HIV-1. Over the past few years, the discovery of some co-factors such as CBF-β, HDAC6 and MDM2 not only raises our awareness of the interaction between APOBEC3G and Vif but also provides new antiviral targets of HIV-1 in addition. Here we review the structure of APOBEC3G and Vif, and the effect of interference agents on HIV-1 replication by interacting with APOBEC3G and Vif.
