Effects of cytomegalovirus infection on structure and function of mitochondria
10.3760/cma.j.issn.1003-9279.2019.01.023
- VernacularTitle: 巨细胞病毒感染对细胞线粒体结构和功能影响的研究进展
- Author:
Xinyan ZHANG
1
;
Feng FANG
Author Information
1. Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
- Publication Type:Review
- Keywords:
Cytomegalovirus;
Mitochondria;
Apoptosis;
Energy metabolism
- From:
Chinese Journal of Experimental and Clinical Virology
2019;33(1):103-107
- CountryChina
- Language:Chinese
-
Abstract:
Cytomegalovirus (CMV) is a kind of common opportunistic pathogenic virus in nature. Infections with human cytomegalovirus (HCMV) always lead to serious consequences among immunodeficiency and immunocompromised individuals. And congenital HCMV infection is the most common cause of newborn malformation which result in neurodevelopmental abnormalities in children. Mitochondria are not only the leading sites of aerobic respiration, but also play important roles in regulating cell growth and cycle. Infection with cytomegalovirus will disrupt the structure of mitochondria and affect the function of mitochondria-associated membrane (MAM). This review summarized the progress about the effects of CMV infection on the structure and function of mitochondria and reveal the role of mitochondria in CMV infection on body damage.
