Study on the association between the efficacy of peg-IFN and the complexity of TP and RT in chronic hepatitis B
10.3760/cma.j.issn.1003-9279.2019.01.017
- VernacularTitle: 慢性乙型肝炎peg干扰素疗效与TP区和RT区核酸研究
- Author:
Tianlin QI
1
;
Xingyue WANG
;
Chongping RAN
;
Weihua CAO
;
Lu ZHANG
;
Yao LU
;
Hongxiao HAO
;
Shuling WU
;
Ruyu LIU
;
Min CHANG
;
Leiping HU
;
Minghui LI
;
Yao XIE
Author Information
1. Dept.of Hepatology Division 2, Liver Diseases Center, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
- Publication Type:Journal Article
- Keywords:
TP region;
RT region;
Peg-interferon a;
Hepatitis B
- From:
Chinese Journal of Experimental and Clinical Virology
2019;33(1):74-78
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between the efficacy of peg-IFN and the complexity of TP and RT regions of hepatitis B virus (HBV) in chronic hepatitis B.
Methods:Patients with HBeAg positive, HBV DNA positive chronic hepatitis B were given peg-interferon 180 μg once a week for subcutaneous injection, and baseline information was collected from baseline and after 12 weeks’ treatment. The baseline HBV DNA TP and RT fragments were amplified, database, high-throughput sequencing, and the average genetic distance calculation.
Results:Data of 108 patients were analyzed by logistic regression. RT area fragment Markov distance and TP area fragment Shannon quotient for HBV DNA response were calculated. ALT level is good for HBeAg response. HBsAg level is bad for HBsAg response.
Conclusions:The complexity of the baseline TP and RT regions may be associated with the efficacy of peg-interferon therapy for CHB.
