Combined treatment of perianal condyloma acuminatum inHIV seropositive men who have sex with men with microwave and photo-dynamic therapy
10.3760/cma.j.issn.1003-9279.2019.01.016
- VernacularTitle: 微波联合光动力治疗男男性接触HIV感染者肛周尖锐湿疣的临床分析
- Author:
Shuifeng LI
1
;
Sihan LU
;
Rongxin HU
;
Jianqun DU
;
Ying LI
;
Junxiong WANG
;
Qiongxian WU
;
Jianyu LIANG
;
QiXian XU
;
Shujuan GUO
Author Information
1. Department of Dermatology, Eighth People′s Hospital of Guangzhou, Guangzhou 510030, China
- Publication Type:Journal Article
- Keywords:
Papillomavirus, human;
Condyloma acuminatum;
Human immunodeficiency virus;
Photodynamic therapy
- From:
Chinese Journal of Experimental and Clinical Virology
2019;33(1):70-73
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical features of perianal condyloma acuminatum in HIV infected men who have sex with men (MSM) and assess the effects of combined treatment of microwave and photodynamic therapy.
Methods:Clinical and laboratory data of 260 male patients with perianal condyloma acuminatum were collected and microwave combined with photodynamic therapy was applied on them.
Results:The majority of the patients with perianal condyloma acuminatum were young people (243/260). Warts were mainly located in the anus or from the outside to inside of the anus (245/260). Among them, the proportion of warts position of extraanal in HIV-infected group (8/220) was lower than that of non-HIV-infected group (7/40). HPV types 11 (70/118), 6 (44/118) and 16 (40/118) were the most common types of HPV infection. People with HIV infection were more likely to develop high-risk, mixed types HPV infection and multiple HPV infection than those without HIV infection. More than half of the patients (146/260) needed only 1-3 sessions of photodynamic treatments. There was no significant difference in the times of photodynamic treatments and the numbers of photosensitizers required between the HIV-infected and non-HIV-infected groups. The recurrence rate of HIV-infected group (13.6%, 30/220) was also similar to that of non-HIV-infected group (15.0%, 6/40), but far lower than those who underwent microwave therapy alone (45%, 18/40).
Conclusions:The combination therapy significantly reduced the recurrence rate of perianal condyloma acuminatum in HIV infected MSM.
