Molecular genotyping for enteroviruses of non-enterovirus 71 non-coxsackievirus A16 associated with hand, foot and mouth disease in Xinjiang
10.3760/cma.j.issn.1003-9279.2019.01.014
- VernacularTitle: 新疆手足口病非EV-A71非CV-A16肠道病毒的基因分型
- Author:
Hong DENG
1
;
Xuan ZHANG
;
Xinxin SONG
;
Yongdi HUANG
;
Jun ZHAO
;
Yierhali AYIGULI.
;
Ruifang HUANG
;
Xihong YUE
Author Information
1. Xinjiang Center for Disease Control and Prevention, Urumqi 830002, China
- Publication Type:Journal Article
- Keywords:
Hand, foot and mouth disease;
Enterovirus;
Pathogen composition
- From:
Chinese Journal of Experimental and Clinical Virology
2019;33(1):61-63
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the pathogenic spectrum characteristics of enteroviruses of non-enterovirus (EV) 71 and non-coxsackievirus (CV) A16 associated with hand, foot and mouth disease (HFMD) in Xinjiang.
Methods:Specimens were collected from HFMD patients infected with non-EV-A71 non-CV-A16 enterovirus from 2011 to 2016 in Xinjiang. The virion protein (VP)1 gene sequence was amplified by reverse transcription polymerase chain reaction (RT-PCR) and sequenced. Sequencing and genotyping were performed through erterovirus genotyping tool.
Results:A total of 119 sequences were obtained, 15 human enterovirus serotypes were identified including CV-A6, CV-A10, CV-A4, CV-A8, CV-B1, CV-B3 (4 strains), CV-B4, CV-B5, ECHO30, ECHO12, ECHO14, CV-A9, CV-A24, PV1 and PV3. The composition ratio of CV-A6 among non-EV-A71 non-CV-A16 enterovirus in 2013, 2015 and 2016 was 87.9%, 79.5% and 88.3% respectively.
Conclusions:The pathogens causing HFMD in Xinjiang included more than 17 kinds of human enterovirus serotypes. Since 2013, CV-A6 has become the main pathogen of HFMD simultaneously or alternately with EV-A71 and CV-A16.
