Virological monitoring and analysis of polioviruses in Qinghai 2017
10.3760/cma.j.issn.1003-9279.2019.01.013
- VernacularTitle: 青海省2017年脊髓灰质炎病毒学监测结果分析
- Author:
Lixia FAN
1
;
Zhuoma BA
1
;
Shengcang ZHAO
1
;
Chonghai LI
1
;
Shuangli ZHU
2
Author Information
1. Qinghai Center for Disease Control and Prevention, Xining 810007, China
2. National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China
- Publication Type:Journal Article
- Keywords:
Acute flaccid paralysis;
Poliovirus;
Virological monitoring
- From:
Chinese Journal of Experimental and Clinical Virology
2019;33(1):58-60
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate 2017 poliovirus surveillance in Qinghai Province.
Methods:According to the World Health Organization (WHO) 4 th edition of the polio laboratory manual procedure for virus isolation, the isolated L20B positive strain was identified as intratypic differentiation (ITD) by the China Center for Disease Control and Prevention, CDC). The National Polio Laboratory performed the nucleotide sequence determination of the capsid protein VP1 coding region of poliovirus (PV) and analyzed the poliovirus surveillance and the result of analysis of the cases with acute flaccid paralysis (AFP) reported in Qinghai Province in 2017 and stool samples of healthy children.
Results:In 2017, Qinghai CDC Polio Laboratory received specimens of 211 AFP cases and healthy stool samples. PV2 strains were isolated with a separation rate of 0.95%. Non-polio enterovirus (NPEV) strains were isolated from 25 strains with the isolation rate of 11.85%. Two PVs were used for ITD. All of them were vaccine-associated strains.
Conclusions:In 2017, the Qinghai CDC Polio Laboratory did not find any poliovirus and vaccine-derived poliovirus in the AFP cases and stool samples from healthy persons, maintaining the polio-free status.
