Application of dendrimer-based siRNA delivery systems
10.11665/j.issn.1000-5048.20190303
- VernacularTitle:树形分子在siRNA递送载体中的应用
- Author:
Gongli CAI
1
;
Yu CHEN
;
Shuting LIN
;
Dandan ZHU
;
Yiwen DONG
;
Ning LI
;
Xiaoxuan LIU
Author Information
1. 中国药科大学天然药物活性组分与药效国家重点实验室；药物科学研究院高端药物制剂与材料研究中心
- Publication Type:Journal Article
- Keywords:
RNA interference;
small interfering RNA;
dendrimers
- From:
Journal of China Pharmaceutical University
2019;50(3):274-288
- CountryChina
- Language:Chinese
-
Abstract:
Small interfering RNA-based RNA interference(RNAi)is an emerging treatment which has attracted more and more attention from both academia and industry. Studies on clinical translation of siRNA are popular in biomedical field, where safe and efficient carriers are necessary. As novel drug/gene vectors, dendrimers are widely used in siRNA delivery due to their unique and precise structure, multiple terminal groups and nano-sized chemophysical properties. Here, we present an overall view of current studies on dendrimer-based siRNA delivery systems, with the aim to provide an understanding of future siRNA therapeutics which could be used in clinic.
