Research advances in hydrogen sulfide donors
10.11665/j.issn.1000-5048.20190302
- VernacularTitle:硫化氢供体分子研究进展
- Author:
Xinxin SHEN
1
;
Yihua ZHANG
;
Zhangjian HUANG
Author Information
1. 中国药科大学新药研究中心
- Publication Type:Journal Article
- Keywords:
H2S donors;
selectivity thiol;
carbonic anhydrase;
carbonyl sulfide
- From:
Journal of China Pharmaceutical University
2019;50(3):265-272
- CountryChina
- Language:Chinese
-
Abstract:
Hydrogen sulfide(H2S)is an endogenous gas messenger molecule with extremely broad biological activities including vasodilation, anti-oxidation, anti-inflammation, cardioprotection and anti-tumor. Similar to other gas messenger molecules, the biological activity of H2S is dependent on its location, concentration and duration of exposure. Therefore, the key scientific issue is how to improve the selectivity of H2S donor molecules to release appropriate concentrations of H2S at the target site(commonly pathological place), exerting therapeutic efficacy with limited side-effects. This article reviews the structures and H2S release mechanisms of two classes of H2S donors focusing on the advances in the recently developed H2S donors with controllable release potential of H2S, thus providing new ideas for future H2S-based drug research.
