Tight junctions-associated proteins:a novel therapeutic target for cholestatic liver injury
10.11665/j.issn.1000-5048.20190203
- VernacularTitle:紧密连接相关蛋白:胆汁淤积性肝损伤治疗的新靶点
- Author:
Xue WANG
1
;
Tingting YANG
;
Zhenzhou JIANG
;
Luyong ZHANG
Author Information
1. 中国药科大学江苏省新药筛选重点实验室
- Publication Type:Journal Article
- Keywords:
cholestatic liver injury;
tight junctions;
barrier function;
bile acid homeostasis;
new targets
- From:
Journal of China Pharmaceutical University
2019;50(2):143-151
- CountryChina
- Language:Chinese
-
Abstract:
The occurrence of cholestatic liver injury is accompanied by the alterations of hepatocyte polarization and bile acid homeostasis. Located in epithelial cells, tight junctions(TJs)are a special barrier structure which are important in maintaining permeability and bile acid homeostasis. Based on the fully analysis and discussion of TJs, the latest therapeutic drugs for cholestasis were summaried, which may provide new perspectives and potential therapeutic agents for the treatment of cholestatic liver injury.
