Research progress of apoptosis signal regulating kinases-1 and its inhibitors in non-alcoholic steatohepatitis
10.11665/j.issn.1000-5048.20190202
- VernacularTitle:凋亡信号调节激酶-1抑制剂在非酒精性脂肪性肝炎中的研究进展
- Author:
Lei HAN
1
;
Xiaomeng ZHANG
;
Xu QUAN
;
Yonghua LEI
;
Hai QIAN
Author Information
1. 中国药科大学新药研究中心；南京圣和药业股份有限公司
- Publication Type:Journal Article
- Keywords:
ASK-1 inhibitors;
non-alcoholic steatohepatitis;
apoptosis signal regulating kinases-1;
advances
- From:
Journal of China Pharmaceutical University
2019;50(2):135-142
- CountryChina
- Language:Chinese
-
Abstract:
Non-alcoholic steatohepatitis(NASH)is the most common chronic liver disease. However, the treatment of NASH remains challenging. Apoptosis signal regulating kinases-1(ASK-1)is a member of mitogen-activated protein kinase kinase kinases(MAPKKKs). When the body is stimulated by reactive oxygen species, endoplasmic reticulum stress, calcium influx and extracellular inflammatory signals, c-Jun amino terminal kinases(JNK)and p38 MAPK wiube activated, which then promotes cell proliferation, differentiation, apoptosis and production of inflammatory factors, and causes NASH, fibrosis and other diseases. Therefore, ASK-1 inhibitors can be used to treat NASH. This paper reviews the current treatment methods of NASH, the structure and mechanism of ASK-1, and the research progress of ASK-1 inhibitors in the treatment of NASH in recent years, which aims to explore the guiding significance for the design and development of ASK-1 inhibitors.
