Advances of relationship between protein O-GlcNAcylation and glucose metabolism in tumors
10.11665/j.issn.1000-5048.20190201
- VernacularTitle:蛋白质O-GlcNAc修饰与肿瘤糖代谢关系的研究进展
- Author:
Weilin ZHANG
;
Xinyi WANG
;
Fang YAN
- Publication Type:Journal Article
- Keywords:
O-GlcNAcylation;
antitumor;
glucose metabolism;
glucose uptake;
glycolysis pentose phosphate pathway;
tricarboxylic acid cycle;
glutamine metabolism
- From:
Journal of China Pharmaceutical University
2019;50(2):127-134
- CountryChina
- Language:Chinese
-
Abstract:
O-GlcNAcylation is the addition of a single N-acetylglucosamine(GlcNAc)moiety to the hydroxyl groups of serine or threonine residues of nuclear and cytoplasmic proteins. The transcription factors, kinases of the metabolic pathways and some cytoplasmic enzymes can be O-GlcNAcylated to affect cell transcription, signal transduction, cell metabolism and other biological functions. Abnormal glucose metabolism of tumors has been a hotspot in the research field of tumor pathogenesis and therapeutic targets recently. O-GlcNAclation regulates the glucose metabolism of tumor by affecting the activity of kinases in the metabolic pathway, which is closely associated with the abnormal glucose metabolism of tumor. The abnormal O-GlcNAcylation is one of the potential reasons of cancer. In this review, in order to provide a theoretical reference for developing anti-tumor targets and drugs targeting O-GlcNAc modification, we briefly summarized how O-GlcNAcylation regulated glucose metabolism on glucose metabolism, glucose uptake, glycolysis, pentose phosphate pathway and tricarboxylic acid cycle in cancer cell.
