Role of non-coding RNA in pulmonary arterial hypertension
10.11665/j.issn.1000-5048.20190115
- VernacularTitle:非编码RNA在肺动脉高压中的作用
- Author:
Yi XU
1
;
Feng YU
;
Yun LIU
Author Information
1. 连云港市第一人民医院药学部；中国药科大学基础医学与临床药学学院
- Publication Type:Journal Article
- Keywords:
non-coding RNA;
pulmonary arterial hypertension;
pathogenesis
- From:
Journal of China Pharmaceutical University
2019;50(1):107-112
- CountryChina
- Language:Chinese
-
Abstract:
Non-coding RNA(ncRNA), a group of RNAs including microRNA, lncRNA, ceRNA, etc. , has multiple functions without protein-coding. It can regulate gene expression through epigenetics by various aspects such as transcription and post-transcription regulation. Recently, a large number of studies have found that ncRNA can cause a variety of diseases, such as cardiovascular disease, cancer, pulmonary arterial hypertension(PAH)and so on. This paper reviews the research progress on the role of ncRNA in PAH formation to provide theoretical foundation for the treatment of PAH.
