Chemical constituents extracted from Dictamnus dasycarpus and their α-glucosidase inhibitory activity
10.11665/j.issn.1000-5048.20190105
- VernacularTitle:白鲜皮化学成分及其α-葡萄糖苷酶抑制活性
- Author:
Xiaojun YANG
1
;
Fengfeng AI
;
Junbing LIN
;
Jiangjiang TANG
Author Information
1. 延安大学化学与化工学院
- Publication Type:Journal Article
- Keywords:
Dictamnus dasycarpus;
chemical constituents;
α-glucosidase;
inhibitory activity;
diabetes
- From:
Journal of China Pharmaceutical University
2019;50(1):41-45
- CountryChina
- Language:Chinese
-
Abstract:
Five compounds were isolated from the petroleum ether extract of Dictamnus dasycarpus using various chromatographic techniques, such as column chromatography over silica gel and Sephadex LH-20. Their structures were elucidated by spectroscopic data(IR, MS, NMR), which were identified as docosanol(1), ethyl 2, 2-dibenzhydryl-3, 3-di-phenylpropionate(2), limonin(3), obacunone(4)and dictamnine(5). Compound 2 was a new compound and compound 1 was isolated from this plant for the first time. PNPG method was used to determine α-glucosidase inhibitory activity of these compounds. The results indicated that compounds 3- 5 possessed stronger inhibitory activities than the positive control of acarbose, which provided a theoretical basis for further development and utilization of Dictamnus dasycarpus.
