The influence from load strength on solute transport rate of lacunar-canalicular system in loaded tibia
10.3871/j.1004-7220.2015.06.515
- VernacularTitle:载荷强度对受载胫骨中骨陷窝-骨小管系统内溶质输运速率影响
- Author:
Yu-kun WANG
1
;
Li-xia FAN
1
Author Information
1. School of Mechanical Engineering, Nanjing University of Science and Technology
- Publication Type:Journal Article
- Keywords:
Lacunar-canalicular system (LCS);
Solute transport;
Load strength;
Bone regeneration
- From:
Journal of Medical Biomechanics
2015;30(6):E515-E520
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence from load strength on solute transport rate in lacunar-canalicular system (LCS) of loaded tibia using finite element method.Methods Based on micro-CT scan images of adult mice tibia, the finite element model of the tibia, which was regarded as being homogeneous biphasic-solute, was established by software of Mimics, Hypermesh and FEBio. The relationship between transport rate and solute diffusivity/load strength was obtained by setting 3 groups of different solute diffusivity (3, 15, 30 μm2/s) and load strength (0.2, 2.0, 5.0 N), respectively. By comparing the results from both fluorescence recovery after photobleaching (FRAP) experiment and finite element method, the effect of load stimulation on transport enhancement was analyzed. Results The transport rate increased with the increase of diffusion rate and load strength. The results from finite element method were basically consistent with the solute transport rules by comparing data from FRAP experiment. Conclusions The research findings can provide some basis for load response and liquidity in deep area of cortical bone, and for further revealing the mechanism of bone regeneration.
