Interleukin-10 Gene Polymorphism in patients with Schizophrenia.
- Author:
Chi Un PAE
1
;
Ju Mi PARK
;
Kwang Soo KIM
Author Information
1. Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Schizophrenia;
IL-10 gene polymorphism
- MeSH:
Alleles;
Diagnostic and Statistical Manual of Mental Disorders;
DNA;
Endopeptidase K;
Haplotypes;
Humans;
Interleukin-10*;
Promoter Regions, Genetic;
Schizophrenia*
- From:Journal of Korean Neuropsychiatric Association
2002;41(6):972-979
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECT: This study was aimed at comparing the Interleukin-10 gene polymorphic variants of patients with schizophrenia with those of normal controls, to investigate its contribution to the development of schizophrenia. METHOD: Two hundred and thirty-three patients with schizophrenia in accordance with DSM-IV criteria and 181 healthy individuals participated in this study. DNA was extracted from whole blood using proteinase K, and the interleukin(IL)-10 gene promoter region was amplified by polymerase chain reaction(PCR). Gene typing was analyzed by restriction fragment length polymorphism(RFLP) and single strand conformation polymorphism(SSCP). RESULTS: Distributions of the alleles and haplotypes of IL-10 gene in patients with schizophrenia were not significantly different from those of controls. There was no difference in the frequencies of alleles and haplotypes between patients with paranoid subtype and with non-paranoid subtype. CONCLUSION: In this study, we found no relataionship between IL-10 gene polymorphic variants and schizophrenia. Further systemic studies including adjacent genes and diverse clinical variables may reveal the effects of IL-10 gene on the susceptibility to schizophrenia.
