Roles of focal adhesion plaques and cytoskeleton in fluid shear stress-induced mechanotransduction
- VernacularTitle:黏着斑-细胞骨架系统介导流体剪切力力转导研究进展
- Author:
Juan XING
1
;
Yan-feng LUO
1
;
Yan LI
1
;
Man-ping LIN
1
;
Li YANG
1
;
Yuan-liang WANG
1
Author Information
1. Key Laboratory of Biorheological Science and Technology (Ministry of Education), College of Bioengineering, Chongqing University
- Publication Type:Journal Article
- Keywords:
Focal adhesion plaque;
Cytoskeletons;
Fluid shear stress;
Mechanotransduction
- From:
Journal of Medical Biomechanics
2014;29(3):E292-E298
- CountryChina
- Language:Chinese
-
Abstract:
Focal adhesion plaques (FAPs) are multi-protein aggregates，which act as physical connections between extracellular matrix and cytoskeleton (CSK). FAPs and CSK play important roles in the conversion of mechanical signals into intracellular chemical signals followed by physiological and pathological responses. With focus on FAPs-CSK system, this review summarized the process of fluid shear stress-induced mechanotransduction and the roles of FAPs and CSK in this process in detail, introduced important proteins in FAPs, discussed the relationship between FAPs and other mechanotransduction pathways. The review established the theoretical foundation for understanding of the relationship between fluid shear stress and shear stress-related diseases, as well as development of clinical drug and treatment of these diseases.
