Pulsatile blood flow in arteries: An analytical and numerical study based on the Womersley algorithm
- VernacularTitle:基于血液流量波及Womersley 算法的动脉血液脉动流研究
- Author:
Jian-hang DU
1
;
Gui-fu WU
2
,
3
;
Zhen-sheng ZHEN
2
;
Gang DAI
2
;
Ming-zhe FENG
2
Author Information
1. Department of Engineering, Guangdong Ocean University；The Key Laboratory on Assisted Circulation, Ministry of Health, Sun Yat-sen University
2. The Key Laboratory on Assisted Circulation, Ministry of Health, Sun Yat-sen University
3. Shenzhen Futian People’s Hospital, Guangdong Medical College
- Publication Type:Journal Article
- Keywords:
Pulsatile blood flow;
Wall shear stress(WSS);
Oscillatory shear index(OSI);
Enhanced external counterpulsation (EECP);
Hemodynamics
- From:
Journal of Medical Biomechanics
2014;29(1):E078-E084
- CountryChina
- Language:Chinese
-
Abstract:
Objective To conduct a comprehensive study on pulsatile blood flow in arteries by proposing a convenient theoretical research system for hemodynamics. Methods Based on Womersley algorithm for fully developed pulsatile flow, numerical algorithm was introduced to establish the solving and analytical system of hemodynamics based on flow rate in arteries during one cardiac cycle. The flow rate of carotid artery in pig was measured under three blood flow states: the ideal state with a sinusoidal inflow waveform, the normal physiological state and the enhanced external counterpulsation (EECP) state for comprehensive hemodynamic research. Results Important hemodynamic parameters such as the axial speed vector, the wall shear stress (WSS), and the oscillatory shear index (OSI) during one cardiac cycle under the mentioned three flow states were solved respectively. The waveform of flow rate had a certain effect on WSS distributions and OSI level; the EECP performance obviously resulted in a significant increase in the level of WSS (WSS peak in particular) and OSI. Conclusions The solving system developed in this paper can be used for hemodynamics study conveniently and effectively. One of the most important hemodynamic mechanisms that lead to EECP’s good clinical effect may lie in its promotion to WSS level under physiological state, but the effect of OSI on endothelial function of the artery might much smaller than WSS itself; therefore, OSI may not be an ideal hemodynamic index for predicting the lesion of atherosclerosis.
