In vitro simulation on haemodynamics of mural coronary artery
- VernacularTitle:壁冠状动脉血流动力学体外模拟
- Author:
Hao DING
1
,
2
;
Lin YANG
3
;
Hai-Lian LAN
2
;
Kun SHANG
1
,
2
;
Shu-ning ZHANG
4
;
Ai-jun SUN
4
;
Ke-qiang WANG
4
;
Li-xing SHEN
1
,
2
;
Jun-bo GE
4
Author Information
1. Shanghai Medical Instrumentation College
2. School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology
3. Research Center，EYE & ENT Hospital, Fudan University
4. Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University
- Publication Type:Journal Article
- Keywords:
Myocardial bridge;
Mural coronary artery;
Atherosclerosis;
Haemodynamic;
Simulative device
- From:
Journal of Medical Biomechanics
2014;29(5):E432-E439
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of myocardial bridge oppression on blood flow, positive pressure, circumferential stress and shear stress of the coronary artery. Methods The original myocardial bridge simulative device was greatly improved to be able to measure multi-hemodynamic parameters, such as normal stress, circumferential stress and shear stress, so as to exactly simulate real blood dynamics environment with the common effect of several stresses, and comprehensively investigate the relationship between hemodynamics and atherosclerosis of mural coronary artery under the combined effects of several stresses. Results The results from the myocardial bridge simulative device indicated that the hemodynamic abnormalities were mainly located in the proximal end of mural coronary artery, and the mean and oscillation values of normal stress at the proximal end were increased by 27.8% and 139%, respectively, showing a significant increase with the intensification of myocardial bridge oppression. Conclusions It is myocardial oppression that causes the hemodynamic abnormity of proximal coronary artery, which is quite important for understanding the hemodynamic mechanism of coronary atherosclerotic diseases and valuable for studying pathological effects and treatments of the myocardial bridge in clinic.
