Setting property and compressive strength of nHA/α-CSH combined bone grafts
- VernacularTitle:nHA/α-CSH复合植骨材料的研制及其固化时间和抗压强度测定
- Author:
Ke-zheng MAO
1
;
Ke-ya MAO
1
;
Zi-shen CHENG
1
;
Peng LI
1
;
Yi-guo WANG
1
;
Bo XIAO
1
;
Jiao XU
1
;
Xiu-mei WANG
2
;
Fu-zhai CUI
2
Author Information
1. Department of Orthopedics, General Hospital of People's Liberation Army
2. Department of Materials Science and Engineering, Tsinghua University
- Publication Type:Journal Article
- Keywords:
Calcium sulfate hemihydrate;
Nanometer hydroxyapatite;
Combined bone grafts;
Setting;
Compressive strength
- From:
Journal of Medical Biomechanics
2013;28(3):E333-E337
- CountryChina
- Language:Chinese
-
Abstract:
Objective To develop a new type of combined bone grafts mainly including nanometer hydroxyapatite (n-HA) and α-calcium sulphate hemihydrate (α-CSH), and investigate its setting property and compressive strength. Methods The setting time and compressive strength of nHA/α-CSH combined bone grafts with different liquid-to-solid (L/S) ratio or calcium sulphate dehydrate (CSD) amount were measured and observed by the X-ray diffraction (XRD) and the scanning electron microscope (SEM). Results The setting time of combined bone grafts was increased along with the increase of L/S ratio or nHA amount, and reduced with the increase of CSD amount. The setting time of the compound with 20% of nHA, 80% of α-CSH was (169±36) min, while that of the compound with 5% of nHA, 20% of CSD, 75% of α-CSH was (6±1.1) min. The compressive strength of combined bone grafts reduced along with the increase of nHA amount. The average compressive strength of pure α-CSH was (12.3±2.4) MPa, while that of the compound with 20% of nHA, 80% of CSH was (4.8±0.6) MPa. The XRD results showed that no other materials were produced except that α-CSH was transformed to CSD during the setting process. The SEM results indicated that nHA was filled in the crystal structure of the CSD, presenting two-phase structure. Conclusions The setting time and compressive strength of nHA/α-CSH combined bone grafts can be adjusted by the different proportion of nHA, CSD amount and L/S ratio, which provides an appropriate condition for clinical application.
