Impacts of surface micro-topography on cellular biological responses
- VernacularTitle:基底微拓扑结构对细胞生物学行为的影响
- Author:
Yuan-wei GONG
1
;
Shu-jin SUN
1
;
Dong-yuan LÜ
1
;
Zhan LI
1
;
Mian LONG
1
Author Information
1. Key Laboratory of Microgravity，Center of Biomechanics and Bioengineering, Institute of Mechanics, Chinese Academy of Sciences
- Publication Type:Journal Article
- Keywords:
Substrate micro-topography;
Cell proliferation;
Stem cell differentiation;
Cytoskeleton
- From:
Journal of Medical Biomechanics
2013;28(1):E109-E126
- CountryChina
- Language:Chinese
-
Abstract:
Culturing cells on planar substrate in vitro is a conventional cell biology method. However, each type of physiological tissues has its specific three-dimensional micro-structure, which provides various micro environment to regulate such biological processes as cell proliferation and differentiation. To date, a growing body of researches on the impacts of substrate micro-topography on cellular responses has been documented in the literature. It is found that micro-topograhical substrate can manipulate cell spreading, migrating, orientating, cytoskeleton remodeling, and stem cell differentiation, which are crucial to ex vivo tissue construction and surface modification of medical implanting materials. This review discusses the recent progresses of the effects of substrate micro-topography on cellular responses and the underlying mechanisms of mechano-biological coupling.
