Experimental study on aerosol particle deposition in human upper respiratory tract model
- VernacularTitle:气溶胶颗粒在人体上呼吸道模型内沉积的实验研究
- Author:
Fu-sheng LI
1
;
Xin-xi XU
1
;
Dong SUN
2
;
Xiu-guo ZHAO
1
;
Meng YANG
1
;
Shu-lin TAN
1
Author Information
1. National Biological Protection Engineering Center, Institute of Medical Equipment, Academy of Military Medical Sciences
2. Institute of Military Transportation of the General Logistics
- Publication Type:Journal Article
- Keywords:
Aerosol;
Human upper respiratory tract;
Particle deposition;
Breathing intensity
- From:
Journal of Medical Biomechanics
2013;28(2):E135-E141
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the aerosol particle deposition in human upper respiratory tract model and explore the pathogenesis of toxic aerosol in human upper respiratory tract. MethodsA human upper respiratory tract model was constructed using ABS (Acrylonitrile Butadiene Styrene) plastic, and an experimental system was established to measure the deposition efficiency of aerosol particles with different diameters (0.3 or 6.5 μm) at different breathing intensity (30 or 60 L/min) in this model. Results The deposition patterns of aerosol particles with different diameters and at different breathing intensity in human upper respiratory tract model were similar. The deposition efficiency was generally higher in pharynx，larynx and trachea while being the highest in the area of larynx. Conclusions The breathing intensity has a major impact on aerosol deposition efficiency in the model. Larger aerosol particles are more easily to deposit in the model. Inertial impaction and turbulence intensity are the main mechanisms of aerosol particle deposition.
