Effects of low-magnitude high-frequency vibration on osteoporotic fracture complicated by closed arterial injuries
- VernacularTitle:低幅高频振动对骨质疏松性骨折合并闭合性动脉损伤的作用
- Author:
Ming-hui SUN
1
;
Ling QIN
2
;
Yong QIU
1
;
Chiu-wing CHU
2
;
Fang-yuan WEI
3
Author Information
1. Department of Spine Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School
2. Department of Orthopeadics & Traumatology,The Chinese University of Hong Kong
3. Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong
- Publication Type:Journal Article
- Keywords:
Low-magnitude high-frequency vibration（LMHFV);
Osteoporosis;
Fracture healing;
Closed arterial injury;
Blood flow velocity
- From:
Journal of Medical Biomechanics
2012;27(2):E145-E151
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of low-magnitude high-frequency vibration (LMHFV) on osteoporotic fracture healing and blood supply of distal injured limbs based on osteoporosis fracture model of the ovariectomized (OVX) rats. Methods Ovariectomy was performed in 32 six-month-old female SD rats. 3 months later, closed transverse fractures were created at the right femoral midshafts complicated by femoral artery injuries. The rats were then randomly divided into vibration group and control group. Radiographs were performed in each week to assess the callus size and the status of fracture healing. At 2nd, 4th and 8th week after treatment, pulsed-wave Doppler ultrasonography was utilized to evaluate the blood flow velocity and the resistance index (RI) of the distal femoral artery in injured limbs. The peri-fracture region was reconstructed by Micro-CT for both qualitative and quantitative analysis. Results Pulsed-wave Doppler indicated a significantly higher peak systolic velocity of distal femoral artery in vibration group at 2nd and 4th week (P<0.05) and a lower RI as compared with control group.Radiography and Micro-CT analysis demonstrated that vibration group had better callus formation, mineralization, remodeling, and bridging rate during fracture healing as compared with control group. Conclusions LMHFV can effectively improve the blood supply of distal injured limbs and promote the osteoporotic fracture healing.
