The research progress of inflammatory reaction in human tissues induced by mechanical force
10.16156/j.1004-7220.2017.05.14
- VernacularTitle:机械力刺激诱导机体组织炎症反应机制研究进展
- Author:
Jia-bao ZHUANG
1
;
Chun XU
1
Author Information
1. Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine；Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology
- Publication Type:Journal Article
- Keywords:
Mechanical force;
Stimulation;
Inflammation;
Cell pyroptosis
- From:
Journal of Medical Biomechanics
2017;32(5):E476-E480
- CountryChina
- Language:Chinese
-
Abstract:
Mechanical forces can induce aseptic inflammatory reactions in human tissues including periodontium, and promote the pyroptosis of immune cells and some non-immune cells such as periodontal ligament cells. Recent studies have revealed that Gasdermin-D (GSDMD) plays an indispensable role in inflammation as well as pyroptosis, while it remains unknown whether GSDMD participates in the mechanical force-induced inflammatory reaction and pyroptosis. The current progress in researches about the mechanical force-induced inflammatory reaction and the signaling pathways of pyroptosis in human tissues is reviewed.
