The roles of STAT3 in osteogenesis of bone mesenchymal stem cells
10.16156/j.1004-7220.2017.01.17
- VernacularTitle:信号转导和转录活化因子3在骨髓基质干细胞成骨向分化中的作用
- Author:
Si-ru ZHOU
1
;
Peng ZHANG
1
;
Ling-yong JIANG
1
Author Information
1. Shanghai Key Laboratory of Stomatology, Department of Oral and Maxillofacial Surgery, Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Bone mesenchymal stem cells (BMSCs);
Signal transducer and activator of transcription 3(STAT4);
Osteogenesis
- From:
Journal of Medical Biomechanics
2017;32(1):E098-E102
- CountryChina
- Language:Chinese
-
Abstract:
Orthodontic tooth movement is a dynamic process, which includes bone resorption on the pressure side and osteogenesis on the tension side. Bone mesenchymal stem cells (BMSCs), which are force-sensitive cells, have potentials for differentiation into cells with various types. Their biological characteristics can change functionally according to the appropriate stimulation in vitro, in order to reach the optimal demand of the stimulation. Many signal pathways are involved in osteogenesis. Signal transducers and activators of transcription 3 (STAT3) is a ubiquitously expressed transcription factor, mediating cell proliferation, differentiation, survival, apoptosis and cellular immunity. It has been reported that STAT3 can regulate the differentiation process of BMSCs into osteoblasts. This paper summarizes the recent progress about effect of STAT3 on bone differentiation of BMSCs and the possible mechanism.
