Effect of Coronary Artery Tortuosity on Coronary Hemodynamics Based on Case Study
10.16156/j.1004-7220.2018.03.07
- VernacularTitle:基于病例研究冠状动脉扭曲对血流动力学的影响
- Author:
Yang LI
1
;
Xu ZHANG
1
;
Zhiyong LI
2
;
Qadir ABDUL
1
;
Qiming DAI
1
;
Jiayi TONG
1
;
Yi FENG
1
;
Chengxing SHEN
3
;
Naifeng LIU
1
;
Genshan MA
1
Author Information
1. Department of Cardiology, Zhongda Hospital, Southeast University
2. School of Biological Sciences and Medical Engineering, Southeast University
3. Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Publication Type:Journal Article
- Keywords:
coronary tortuosity;
hemodynamics;
wall shear stress (WSS);
atherosclerosis
- From:
Journal of Medical Biomechanics
2018;33(3):E229-E233
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the hemodynamic changes in a tortuous coronary to elucidate the effects of tortuosity on coronary perfusion and wall shear stress (WSS). Methods A single tortuous and non-tortuous patient-specific left anterior descending (LAD) coronary artery cases were selected. Two LAD models with and without coronary tortuosity were reconstructed in Mimics software and then transferred to the ANSYS Fluent software for performing computational fluid dynamics (CFD) simulation. The hemodynamic characteristics of both the LAD models were compared. Results The vessel WSS of the tortuous coronary artery clearly decreased in the bend section where the maximum curvature was larger than 1 mm-1.Such a scenario could led to an inadequate blood supply in the downstream vessels. A low WSS (0-26 Pa) acted on the outer wall of the bend, whereas the inner wall of the bend had a high WSS (>100 Pa). The mean WSS of the non-tortuous and tortuous models was 10.79 Pa and 36.12 Pa, respectively. The overall WSS of the tortuous model was larger compared with that of the non-tortuous model. Conclusions Coronary tortuosity increased the overall WSS, which could delay the progress of coronary atherosclerosis.
