The Role of Notch Signaling in Bone Remodeling

VernacularTitle:Notch信号通路在骨重建中的作用
Author: Zihao HE ¹ ; Zhifeng YU ¹
Author Information

1. Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Publication Type:Journal Article
Keywords: Notch signaling pathway; bone remodeling; osteoblast; osteocyte; osteoclast
From: Journal of Medical Biomechanics 2018;33(1):E089-E094
CountryChina
Language:Chinese
Abstract: Notch signaling pathway has a wide range of effects in the field of embryonic development, nervous system, vascular system, endocrine system and tumor. In recent years, studies have shown that Notch plays an important role in the regulation of bone metabolism, especially in bone remodeling. The disorder of bone remodeling is closely related to the progress of diseases such as osteoporosis and osteoarthritis. Notch signaling pathway can affect the process of bone remodeling by regulating the function of different cells in bone tissues, but its specific participation in different cells is still unknown. This review summarizes recent advances about the role of Notch signaling in bone remodeling.