In Vivo Degradation Performance of High-Purity Magnesium Subjected to Quantitative Mechanical Load
10.16156/j.1004-7220.2018.05.06
- VernacularTitle:高纯镁在体内定量载荷下的降解行为
- Author:
Yuanming GAO
1
,
2
;
Kuo ZHANG
3
;
Lizhen WANG
1
,
2
;
Linhao LI
1
,
2
;
Haiming SUN
3
;
Yubo FAN
1
,
2
,
4
Author Information
1. Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University
2. Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University
3. Department of Laboratory Animal Science, Health Center, Peking University
4. National Research Center for Rehabilitation Technical Aids
- Publication Type:Journal Article
- Keywords:
stress corrosion cracking;
degradable material;
high-purity magnesium;
in vivo experiment;
quantitative load
- From:
Journal of Medical Biomechanics
2018;33(5):E417-E422
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of mechanical load on in vivo degradation performance of high-purity magnesium (HP Mg, 99.99 wt.%) quantitatively. Methods Cylindrical Mg specimens, with a 2 mm diameter and a 14 mm length, were mounted in polyetheretherketone (PEEK) rings to bear compressive stresses ［（6.2±0.6） MPa］, tensile stresses ［（4.6±0.1） MPa］ or no stress (as control). The specimens under different stress states were implanted subcutaneously in dorsal abdominal regions of SD rats for 4 weeks. The mass loss, residual volume and surface morphology of the specimens and staining of surrounding soft tissues were used to analyze the degradation rate of HP Mg. Results Specimens and rings were completely encapsulated by membranous tissues after implantation for 4 weeks. No significant differences in the degradation rates were noted between specimens bearing stress and the control. The corrosion layers of specimens under each stress state were uniform. Conclusions The compressive and tensile stresses (4-6 MPa) could not affect significantly HP Mg degradation performance in vivo. The research findings provide theoretical references for the design and clinical application of Mg-based degradable implants.
