Research progress on Mechanism of Fluid Shear Stress in Osteogenesis of Bone Mesenchymal Stem Cells
10.16156/j.1004-7220.2018.04.15
- VernacularTitle:流体剪应力在骨髓基质干细胞成骨向分化中作用机制的研究进展
- Author:
Yiling YANG
1
;
Peng ZHANG
2
;
Lingyong JIANG
1
Author Information
1. Department of Oral and Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
2. Second Dental Center, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
fluid shear stress (FSS);
bone mesenchymal stem cells (BMSCs);
mechanotransduction;
mechanosensitivity
- From:
Journal of Medical Biomechanics
2018;33(4):E378-E382
- CountryChina
- Language:Chinese
-
Abstract:
Cells are exposed to mechanical stress, such as fluid shear stress (FSS), mechanical strain, hydrostatic pressure in vivo. FSS is considered to be the most important stress during bone homeostasis and remodeling. At present, most studies are mainly about the FSS effect on osteocytes and osteoblasts. However, the effects of FSS on bone mesenchymal stem cell (BMSCs) are not fully understood. BMSCs are of great significance in bone reconstruction and clinical treatment, so researchers increasingly focus on the response of BMSCs to FSS. The response of BMSCs to FSS depends on the alteration of cytoskeleton, matrix stiffness and elasticity, osteogenic signaling pathways and so on. In this review paper, the recent researches about the mechanotransduction mechanism of FSS, and its effect on differentiation and function of BMSCs are summarized, so as to provide new insights for studying construction of tissue engineered bone and treatment of bone diseases.
