A Review on Mock Circulatory Systems for in vitro Hemodynamic Performance Evaluation of Ventricular Assist Devices
10.16156/j.1004-7220.2018.04.13
- VernacularTitle:用于心室辅助装置血流动力学性能评价的体外模拟循环系统技术进展
- Author:
Penghui HUANG
1
;
Zhongyu HUANG
1
;
Weiguo DANG
1
;
Yawei WANG
2
;
Boling XU
1
Author Information
1. Artificial Organ Technology Lab, Biomanufacturing Research Centre，School of Mechanical and Electrical Engineering, Soochow University
2. College of Biological and Medical Engineering, Beijing University of Aeronautics and Astronautics
- Publication Type:Journal Article
- Keywords:
mock circulatory system (MCS);
hemodynamics;
ventricular assist device (VAD);
human circulatory system;
artificial heart
- From:
Journal of Medical Biomechanics
2018;33(4):E365-E371
- CountryChina
- Language:Chinese
-
Abstract:
Mock circulatory system (MCS) is an experimental platform for simulating hemodynamic performance of human circulatory system, and has been widely used in in-vitro hemodynamic performance evaluation of passive devices such as ventricular assist devices (VADs), artificial valves, as well as hemodynamic responses of mock circulation loop. MCSs are capable of simulating various physiological conditions, including health, exercise, and heart failure, by adjusting drive element of heart simulator and lumped-parameter element of vasculature components. Since 1 960 s, the research and development target of MSCs has evolved from meeting the basic performance evaluation requirement of VADs and mechanical valve to mimicking local hemodynamic characteristics in vital organs. This review summarizes the design principles, system construction of MCSs as well as its research progress and future prospects.
