Safety and efficacy of citrate anticoagulation for septic patients with liver patients
10.3760/cma.j.issn.1672-7088.2019.32.002
- VernacularTitle: 枸橼酸抗凝在脓毒症合并肝功能不全患者持续肾脏替代治疗期间的安全性及有效性研究
- Author:
Yan CAO
1
;
Dan QIAN
1
;
Hong PAN
2
;
Peng ZHUANG
1
;
Xin ZHANG
1
Author Information
1. Intensive Care Unit of Wuxi People′s Hospital,Wuxi 214023, China
2. Nursing Department of Wuxi People′s Hospital, Wuxi 214023, China
- Publication Type:Journal Article
- Keywords:
Citrate anticoagulation;
Liver dysfunction;
Septic
- From:
Chinese Journal of Practical Nursing
2019;35(32):2488-2491
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of citrate anticoagulation for continuous renal placement therapy (CRRT) in septic patients with liver dysfunction.
Methods:The data of septic patients who needed to CRRT and were admitted into the department of critical care medicine from January 2016 to December 2017 were enrolled in this study. Liver dysfunction was defined as Child-Turotte-Pugh (CTP) score >4. A total of fifty-six patients met the criteria. According to the patient′s actual condition, they were divided into citrate groups (29 cases) and low molecular weight heparin (LMWH) group (29 cases). Patients in LMWH group were given slow molecular weight heparin. The efficacy and safety were compared between the two groups. The filter lifetime, after treatment the activated partial thromboplastin time (APTT),hemoglobin (Hb) were compared between the two groups.
Results:The average filter lifetime in citrate group was (25.0±12.2) h which was longer than (13.7±4.5) h in LMWH group (t=13.17, P<0.01). The average service life of each filter was (4.2±1.9) h which was lower than (8.7±3.6) in LMWH group (t=8.395, P<0.05).
Conclusions:Regional Citrate anticoagulation is a safe and effective option for CRRT in septic patients with liver dysfunction, without causing electrolyte disturbance and internal environment.
