Efficacy of pranoprofen combined with 0.3% hyaluronic acid sodium eye drops in the treatment of dry eye after cataract surgery
10.3760/cma.j.issn.1008-6706.2019.24.017
- VernacularTitle: 普拉洛芬联合0.3%玻璃酸钠滴眼液治疗白内障术后干眼症的疗效分析
- Author:
Jing ZHAO
1
;
Weiwei CHEN
2
;
Zhongping JIN
1
Author Information
1. Department of Ophthalmology, the Traditional Chinese Medicine Hospital of Yiwu, Yiwu, Zhejiang 322000, China
2. Department of Pathology, Fuyuan Private Hospital of Yiwu, Yiwu, Zhejiang 322000, China
- Publication Type:Journal Article
- Keywords:
Xerophthalmia;
Postoperative complications;
Cataract extraction;
Patient satisfaction;
pralofen;
Ali eye drops
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(24):3011-3014
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of pranoprofen combined with 0.3% hyaluronic acid sodium eye drops on dry eye after cataract surgery.
Methods:From July 2016 to June 2018, 80 patients with dry eye after cataract surgery in the Traditional Chinese Medicine Hospital of Yiwu were selected study objects, and they were randomly divided into control group and observation group by double blind random assignment method, with 40 cases in each group.The control group was treated with pranoprofen eye drops alone, while the observation group was treated with pranoprofen eye drops combined with 0.3% hyaluronic acid sodium eye drops.The lacrimal gland secretion, corneal fluorescein staining (FL) and corneal rupture time (BUT) were observed before and after treatment in the two groups.The improvement of dry eye symptoms, ocular surface signs score and life satisfaction were observed in the two groups.
Results:There were no statistically significant differences in lacrimal gland secretion test, FL and BUT test before treatment between the two groups (all P>0.05). The lacrimal gland secretion test, BUT and FL in the control group were (6.44±0.32)mm/5 min, (1.60±0.45), (4.31±0.23)s, respectively, which in the observation group were (9.03±0.86)mm/5 min, (0.66±0.25), (5.20±0.33)s, respectively, the differences were statistically significant(t=17.79, 11.43, 13.59, all P<0.05). In the control group, significant improvement in dry eye symptoms observed in 26 cases, slightly improved in 9 cases, no improvement in 5 cases, which in the observation group were 32 cases, 8 cases, 0 case, and there was statistically significant difference between the two groups (Z=0.342, P=0.006). Ocular surface signs analysis: before treatment, the score of the control group was (3.61±1.33)points, which of the observation group was (3.65±1.27)points, the difference was not statistically significant (P=0.051); after treatment, the score of the control group was (1.97±1.21)points, which of the observation group was (1.32±0.91)points, the difference was statistically significant (t=4.673, P=0.003). Life satisfaction score: after 1, 2 and 3 weeks of treatment, the control group was (20.62±3.17)points, (22.35±2.17)points, (29.16±3.19)points respectively, and the observation group was (23.32±2.16)points, (27.41±2.51)points, (33.11±4.15)points respectively, the differences are statistically significant between the two groups(t=6.29, 8.34, 6.31, P=0.002, 0.005, 0.013).
Conclusion:Pranoprofen combined with hyaluronic acid sodium eye drops has significant effect in the treatment of dry eye after cataract surgery.
