Influence of compound salvia injection on oxidative stress and complications in patients with gestational hypertension
10.3760/cma.j.issn.1008-6706.2019.24.012
- VernacularTitle: 复方丹参注射液对妊娠期高血压疾病患者氧化应激及分娩并发症的影响
- Author:
Ning LI
1
;
Wenling GUO
1
;
Jianlin MA
2
;
Xiuping CHEN
3
;
Dianwei WANG
1
Author Information
1. Department of Obstetrics, Binzhou Central Hospital, Binzhou, Shandong 251700, China
2. Department of Emergency, Binzhou Central Hospital, Binzhou, Shandong 251700, China
3. Department of Ultrasound, Binzhou Central Hospital, Binzhou, Shandong 251700, China
- Publication Type:Journal Article
- Keywords:
Hypertension, pregnancy-induced;
Oxidative stress;
Inflammation;
Pregnancy complications;
Parturition;
Blood pressure;
Pregnancy outcome;
Compound salvia injection
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(24):2988-2992
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the influence of compound salvia injection on oxidative stress and complications in patients with gestational hypertension.
Methods:From August 2015 to Fabuary 2017, 140 patients with gestational hypertension in Binzhou Central Hospital were selected as study objects, and randomly divided into control group and research group according to the digital table, with 70 cases in each group.The control group was treated with routine treatment, the research group was given routine treatment combined with compound salvia injection.After treatment, SOD, MDA, NO, HMGB1, Cys C, hs-CRP, TNF-α, blood pressure and complications between the two groups were compared.
Results:After treatment, the levels of NO[(942.58±80.69)mmol/L vs.(734.51±78.63)mmol/L] and SOD[(124.65±23.81)U/mL vs.(90.64±24.13)U/mL] in the research group were higher than those in the control group, and the MAD level[(10.47±3.14)nmol/L vs.(15.82±3.32)nmol/L]in the research group was lower than that in the control group, the difference were statistically significant between the two groups(t=15.451, 8.394, 9.795, all P<0.05). After treatment, the levels of HMGB1[(1.81±0.43)mg/L vs.(3.89±0.65)mg/L], Cys C[(1.04±0.18)mg/L vs.(1.42±0.27)mg/L], TNF-α[(15.09±3.14)ng/L vs.(21.45±4.78)ng/L] and hs-CRP[(3.04±0.81)mg/L vs.(6.32±1.45)mg/L] in the research group were lower than those in the control group, the differences were statistically significant(t=22.329, 9.798, 9.304, 16.523, all P<0.05). After treatment, the systolic blood pressure[(131.25±5.74)mmHg vs.(139.61±5.59)mmHg] and diastolic blood pressure[(85.23±5.07)mmHg vs.(90.43±5.81)mmHg] in the research group were lower than those in the control group(t=8.730, 5.642, all P<0.05). The cesarean section rate(61.43% vs.87.14%) and intrauterine distress rate(1.43% vs.11.43%) in the research group were lower than those in the control group(χ2=12.115, 5.818, all P<0.05).
Conclusion:Compound salvia miltiorrhiza injection has significant control effect on oxidative stress and inflammatory reaction in patients with gestational hypertension, and is beneficial to reduce the complications of childbirth.
