Advance on voltage-gated chloride channel and epilepsy

VernacularTitle: 电压门控氯离子通道与癫痫研究进展
Author: Hailan HE ¹ ; Jing PENG
Author Information

1. Department of Pediatrics, Xiangya Hospital of Central South University, Changsha 410000, China
Publication Type:Review
Keywords: Voltage-gated chloride channel; Chloride ion; Epilepsy; Gene
From: Chinese Journal of Applied Clinical Pediatrics 2019;34(24):1911-1914
CountryChina
Language:Chinese
Abstract: Epilepsy is one of the most common chronic neurological diseases, which results from diverse etiologies, and its mechanism is very complicated.Ion channel gene mutation is a common genetic cause of epilepsy.Voltage-gated chloride channels (ClCs) can change the chloride ion concentration and electric potential difference across the plasma membrane, and thereby regulate the electrical excitability of neurons.CLCN-1, CLCN-2, CLCN-3, CLCN-4 and CLCN-6 are reported to be associated with epilepsy, which could increase susceptibility to epilepsy or cause seizures.This review is focused on recent advances in ClCs and epilepsy.