A wave is a marker in demyelination subtype in children′s Guillain-Barré syndrome and it correlates with short-term prognosis
10.3760/cma.j.issn.2095-428X.2019.24.007
- VernacularTitle: A波为儿童吉兰－巴雷综合征脱髓鞘标志并与短期预后相关
- Author:
Ruidi SUN
1
;
Xiaoli YU
1
;
Lin CUI
1
;
Xiaoqing LUO
1
;
Hongmin ZHU
2
;
Jun JIANG
1
;
Zhisheng LIU
2
Author Information
1. Department of Electrophysiology, Wuhan Children′s Hospital Affiliated to Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430016, China
2. Department of Neurology, Wuhan Children′s Hospital Affiliated to Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430016, China
- Publication Type:Journal Article
- Keywords:
A wave;
Child;
Guillain-Barré syndrome
- From:
Chinese Journal of Applied Clinical Pediatrics
2019;34(24):1867-1870
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the A wave value in neuroelectrophysiological subtype of Guillain-Barré syndrome(GBS)and the clinical severity and short-term prognosis of acute inflammatory demyelinating polyradiculoneuropathy(AIDP).
Methods:From March 2014 to March 2017, a total of 56 children with GBS at Department of Neurology of Wuhan Children′s Hospital Affiliated to Tongji Medical College, Huazhong University of Science & Technology were enrolled.The patients were divided into AIDP subtype(40 cases) and axonal GBS subtype(16 cases) according to the results of electrophysiological examination.According to whether there was existence of A wave or not, the GBS children were divided into 2 groups.The first group was the A wave in GBS group(18 cases), and the second group was non-A wave in GBS group(38 cases). In order to explore classification value for GBS with A wave, clinical data including age, gender, history of prodromal infection, cranial nerve dysfunction, autonomic nerve involvement and conduction blocks were analyzed.To explore A wave value in clinical severity and short-term prognosis of AIDP, the age, gender, clinical severity, conduction blocks, short-term prognosis of the 2 groups were analyzed in A wave with AIDP (18 cases) and non-A wave with AIDP(22 cases).
Results:Compared with non-A wave GBS patients, A wave GBS patients had more conduction blocks(10 cases vs.2 cases, χ2=18.021, P=0.000). Age, sex, precedent infections, cranial nerve involvement, autonomic nerve involvement were not significantly statistically different(all P>0.05). A wave was only seen in AIDP subtype(18 cases), and the percentage of A wave in AIDP was 45%(18/40 cases). There was no A wave in axonal GBS.Compared with non-A wave in AIDP, A wave in AIDP patients had more conduction blocks(10 cases vs.2 cases, χ2=9.924, P=0.002), poorer clinical motor function[(3.39±1.09) scores vs.(2.50±1.01) scores, t=2.667, P=0.011]and short-term prognosis[(2.06±0.64) scores vs.(1.55±0.60) scores, t=2.607, P=0.013].
Conclusions:A wave is correlated with demyelination subtype in children′s Guillain-Barré syndrome and poor short-term prognosis in AIDP.
