IgA nephropathy over 40 years.
- Author:
Chun Gyoo IHM
1
Author Information
1. Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
- Publication Type:Review
- Keywords:
IgA nephropathy;
Pathogenesis;
Undergalactosylated IgA1;
Bone marrow disorder;
Chronic renal failure
- MeSH:
Glomerulonephritis, IGA;
Immunoglobulin A;
Kidney Failure, Chronic;
Prognosis
- From:Korean Journal of Medicine
2009;77(4):435-443
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
IgA nephropathy is characterized by the predominant deposition of IgA in a granular fashion diffusely in the mesangial zones of glomeruli. IgA nephropathy was first described over four decades ago and is now the most common form of primary glomerular disease. Much progress has been made in the elucidation of potential pathogenetic mechanisms such as undergalactosylated IgA1 as well as in the fields of clinical features, prognosis, and treatment. This knowledge is being applied in the development of new diagnostic methods and hopefully in the future the creation of novel and rational therapeutic approaches.
