Study of peripheral blood T lymphocyte subsets CD45RA+ and CD45RO+ in children withHenoch-Schonlein purpura
10.3760/cma.j.issn.1008-6706.2019.23.005
- VernacularTitle: 过敏性紫癜患儿外周血T淋巴细胞亚群CD45RA＋、CD45RO＋表达的研究
- Author:
Jiahao CHEN
1
;
Ziwei YANG
;
Jianjun WANG
Author Information
1. Department of Pediatrics, theAffiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China
- Publication Type:Journal Article
- Keywords:
Purpura, schoenlein-henoch;
Child;
Blood cells;
T-lymphocyte subsets;
Allergy and immunology;
Antigens, CD45;
Flow cytometry;
T-lymphocytes, regulatory
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(23):2835-2839
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the change and clinical significance of the peripheral blood T-lymphocytes CD45RA+ and CD45RO+ in children with Henoch-Schonlein purpura (HSP) under different clinical classification.
Methods:From October 2015 to July 2017, the clinical data of 80 children with HSP in the Affiliated Hospital of North Sichuan Medical College were retrospectively analyzed.According to the clinical classification, they were divided into three groups: skin involvement group (35 cases), abdominal type group (36 cases), and renal type group (9 cases). Another 80 healthy children were selected as the control group.The changes and clinical significance of peripheral blood T-lymphocytes CD45RA+ , CD45RO+ and CD45RA+ /CD45RO+ ratio were analyzed.
Results:Among the 80 children, 40 cases were male and 40 cases were female, with age of (7.2±2.3)years old.The CD45RA+ and CD45RO+ rates in the HSP group were (13.19±7.09)%, (12.07±3.46)%, respectively, which were significantly lower than those in the control group [(23.26±6.01)%, (21.74±3.46)%], the differences were statistically significant (t=9.69, 16.42, all P<0.05). The CD45RA+ ratio, CD45RA+ count and CD45RA+ /CD45RO+ ratio of the kidney type group were (8.02±3.63)%, (2.19±0.33)/μL, (-0.28±0.19), respectively, which were significantly lower than those of the skin group [(15.74±7.71)%, (2.55±0.33)/μL, (0.27±0.12)], the differences were statistically significant(t=3.085, 2.709, 4.013, all P<0.05). The ratio of CD45RA+ /CD45RO+ in the abdominal group was significantly lower than that in the skin group[(-0.07±0.27)vs.(0.27±0.12), t=2.989, P<0.05].
Conclusion:Peripheral blood T lymphocyte subsets CD45RA+ and CD45RO+ may play a role in the generation and development of immune function changes in children with HSP, and the decrease of CD45RA+ T cells may be related to the risk of HSP nephritis.
