Changes and clinical significance of prolactin and estrogen levels in women with autoimmune thyroid disease
10.3760/cma.j.issn.1008-6706.2019.23.003
- VernacularTitle: 女性自身免疫性甲状腺疾病患者血清催乳素、雌激素水平变化及临床意义
- Author:
Yamin LU
1
;
Guangxia LIU
1
;
Fang CHEN
1
;
Zhan HOU
1
;
Cuigai ZHANG
2
;
Tianpei LI
3
Author Information
1. Department of Nuclear Medicine, the People's Hospital of Hebei Province, Shijiazhuang, Hebei 050051, China
2. Department of Physical Examination Center, the People's Hospital of Hebei Province, Shijiazhuang, Hebei 050051, China
3. Shijiazhuang Dongyuan Community Service Center, Shijiazhuang, Hebei 050051, China
- Publication Type:Journal Article
- Keywords:
Thyroid disease;
Estrogens;
Prolactin;
Interleukin-2;
Interleukin-6;
Interleukin-10;
Thyroid hormones;
Female
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(23):2826-2829
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the changes and clinical significance of serum prolactin and estrogen levels in women with autoimmune thyroid diseases.
Methods:From January 2018 to December 2018, 76 newly diagnosed female patients with autoimmune thyroid diseasein outpatient and inpatient clinics of the People's Hospital of Hebei Province were selected as study group, including 40 cases of Graves' disease and 36 cases of hashimoto's thyroiditis.And 60 healthy women with age matched were selected as control group.Serum estrogen, prolactin, thyroid hormone and their antibodies, IL-2, IL-6, IL-10 and other related indicators were determined before and after treatment, and the correlation analysis was performed.
Results:The levels of estrogen[(302.85±78.62)ng/L], prolactin [(15.98±4.18)μg/L], IL-2 [(224.45±61.28)ng/L], IL-6 [(211.46±67.25)ng/L] in the study group were all higher than those in the control group [(228.4±71.38)ng/L, (10.35±3.21)μg/L, (120.34±38.27)ng/L, (165.51±50.09)ng/L], and the IL-10 level in the study group was lower than that in the control group [study group: (15.65±4.86)ng/L; control group: (20.12±4.83)ng/L] , there were statistically significant difference between the two groups(t=5.78, 3.11, 8.98, 3.94, all P<0.05). After treatment, the levels of estrogen [(237.11±70.42)ng/L], prolactin[(10.40±3.32)μg/L], IL-2[(122.67±38.99)ng/L], IL-6[(166.24±52.09)ng/L] in the study group were significantly decreased compared with before treatment(t=5.56, 3.76, 9.04, 4.02, all P<0.05), and the IL-10 level [(19.96±4.93)ng/L] was significantly increased (t=3.95, P<0.05). However, there was no statistically significant difference in thyroid antibody between the two groups (P>0.05). Estrogen level was positively correlated with prolactin, IL-2 and IL-6(r=0.327, 0.298, 0.336, all P<0.01), and negatively correlated with IL-10(r=-0.285, P<0.05).
Conclusion:Elevated levels of estrogen and prolactin can stimulate the production and release of inflammatory cytokines, thus affecting the level of thyroid hormone, which is closely related to the female autoimmune thyroid disease.
