Association between corticotropin releasing hormone receptor 1 (rs4458044) polymorphism and persistent pulmonary hypertension of the newborn
10.3760/cma.j.issn.2095-428X.2019.23.009
- VernacularTitle: 促肾上腺皮质激素释放因子受体1基因(rs4458044)多态性与新生儿持续性肺动脉高压的相关性研究
- Author:
Cui LI
1
;
Xuehui ZHANG
;
Xueyun REN
;
Fang YOU
Author Information
1. Department of Pediatrics, Affiliated Hospital of Jining Medical College, Jining 272000, Shandong Province, China
- Publication Type:Journal Article
- Keywords:
Corticotropin releasing hormone receptor 1;
Polymorphism;
Persistent pulmonary hypertension;
Infant, newborn
- From:
Chinese Journal of Applied Clinical Pediatrics
2019;34(23):1796-1798
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between rs4458044 site of corticotropin releasing hormone receptor 1 (CRHR1) polymorphism and persistent pulmonary hypertension of the newborn (PPHN).
Methods:Eighty-five blood specimens were collected from newborns with PPHN in Affiliated Hospital of Jining Medical University between March 2012 and March 2018, and 50 blood specimens were collected from healthy newborns as controls.The basic clinical data, clinical laboratory results, distribution of CRHR1 (rs4458044) polymorphism were retrospectively analyzed by t-test and χ2 test.
Results:No significant difference existed in gender, gestational age, birth weight and 1 minute Apgar score between newborns with PPHN and the normal controls (all P>0.05). Significant difference existed in auxiliary ventilation time and maximum oxygenation index between newborns with PPHN and the normal controls (all P<0.05). Gene frequency of CRHR1 (rs4458044) GG, CG and CC gene types in newborns with PPHN and controls was 2.35%, 43.53%, 54.12% and 50.00%, 38.00%, 12.00%, respectively.The CG/CC gene type was significantly higher in newborns with PPHN than the normal controls (P<0.05). The CG/CC gene type newborns had a higher risk for getting PPHN than GG gene type newborns (GG gene type as reference, CG gene type OR=24.34, 95%CI: 5.20-113.87, P=0.00; CC gene type OR=95.83, 95%CI: 17.99-510.49, P=0.00). Auxiliary ventilation time and maximum oxygenation index of newborns carrying C allele were higher than those without carrying C allele.
Conclusion:CRHR1 (rs4458044) polymorphism is closely associated with PPHNs.
