Investigation on epidemiology of nosocomial sepsis of premature infants with gestational age less than 34 weeks in Shaanxi province: a multicenter study
10.3760/cma.j.issn.2095-428X.2019.23.004
- VernacularTitle: 陕西省住院新生儿出生胎龄<34周早产儿院内感染败血症多中心流行病学调查
- Author:
Jinzhen GUO
1
;
Hong JIANG
2
;
Wenping SONG
3
;
Yanni ZHANG
4
;
Xiaolin ZHAO
1
;
Yunfan YANG
1
;
Di ZHAO
1
;
Pengfei QU
1
;
Zhankui LI
1
Author Information
1. Department of Neonatology, North-West Women and Children′s Hospital, Xi′an 710061, China
2. Department of Neonatology, Hospital of Yan′an University, Yan′an 716000, Shaanxi Province, China
3. Department of Neonatology, Weinan Maternal and Children′s Health Hospital, Weinan 714000, Shaanxi Province, China
4. Department of Neonatology, Ankang Maternal and Children′s Health Hospital, Ankang 725000, Shaanxi Province, China
- Publication Type:Journal Article
- Keywords:
Infant, premature;
Sepsis;
Multi-center study;
Pathogen
- From:
Chinese Journal of Applied Clinical Pediatrics
2019;34(23):1774-1777
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the epidemiological data of nosocomial sepsis of premature infants with gestational age less than 34 weeks and the distribution characteristics of pathogenic bacteria in Shaanxi province.
Methods:A retrospective analysis of clinical data of premature infants born with gestational age < 34 weeks born between January 1 and December 30, 2018 in Neonatal Intensive Care Units(NICU) in 4 Grade A Class Three hospitals in Shaanxi province was performed.The high risk factors and pathogenic bacteria were analyzed by using chi-square test and t test for statistical analysis.
Results:Totally 823 infants were included in this study, among whom, 73 patients developed nosocomial sepsis, and the incidence was 8.9%.The mean gestational age of the 73 patients with nosocomial sepsis was (30.6±2.2) weeks and mean birth weight was (1 320.3±450.5) g. The rate of invasive ventilator was 23.4%(52/222 cases). The rate of peripherally inserted central catheter (PICC) was 20.1% (61/303 cases). The rate of early antibiotic use was 8.1% (39/481 cases) and breast feeding rate was 9.3% (63/675 cases). The rate of PICC and ventilator use were statistically different between the non-infection group and the infection group(all P<0.05). There were 31 strains of pathogenic bacteria, among which gram-negative bacilli was the most common (22 strains, 70.9%), which mainly were klebsiella pneumoniae strains (15 strains, 48.4%), and 6 strains(19.4%) of Fungus was detected.
Conclusions:The incidence of nosocomial sepsis in NICU in Shaanxi province is higher, gram-negative bacilli was the most common pathogenic bacteria, among which, klebsiella pneumoniae was main, it is necessary to strengthen the regular monitoring and analysis of nosocomial infection in NICU in order to reduce the incidence of nosocomial infection and sepsis.
